Domestic flights depart from Guwahati Airport and arrive in Delhi, Kolkata, Ahmedabad, Bangalore, Mumbai, Chennai, Goa, Hyderabad, Jaipur, Agartala, and other cities in North Eastern India like Imphal, Silchar, Jorhat, Itanagar, Shillong, and Tawang. Domestic flights departing from the Guwahati airport are serviced by Air India, IndiGo, Jet Airways, GoAir, Jet Konnect, SpiceJet, and JetLite. Druk Air manages the international flights from Guwahati, which travel to Bangkok.

The airport in Guwahati is a major international hub and features two separate terminals. Domestic flights depart from Terminal 1 and connect to about ten other cities within India. It is estimated that 500 passengers per hour can be accommodated at the domestic terminal during peak hours. The capacity of Terminal 2, the international terminal, is 125 passengers. There are 14 check-in desks, 1 customs desk, and 4 immigration desks between the terminals.

The airport provides free use of baggage carts for the comfort of its visitors. The airport also features a lost and found medical center, a play area for kids, a business center, and wheelchair access for the elderly and disabled.